PHC-011 Dual Absorption in Intranasal Administration: A New Pharmacokinetic Model
نویسندگان
چکیده
منابع مشابه
Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration.
Intranasal (IN) administration could be an attractive mode of delivery for drugs targeting the central nervous system, potentially providing a high bioavailability because of avoidance of a hepatic first-pass effect and rapid onset of action. However, controversy remains whether a direct transport route from the nasal cavity into the brain exists. Pharmacokinetic modeling is proposed to identif...
متن کاملA new physiologically based pharmacokinetic model for the prediction of gastrointestinal drug absorption: translocation model.
This study aimed to construct a new local pharmacokinetic model of gastrointestinal absorption, the translocation model (TLM), using an anatomically relevant, minimally segmented structure to explain linear and nonlinear intestinal absorption, metabolism, and transport. The TLM was based on the concept of a single absorption site that flexibly moves, expands, and shrinks along with the length o...
متن کاملIntranasal administration of drugs.
OBJECTIVE To investigate how nasally applied substances distribute in the nose depending on the form of application. DESIGN Observer-blinded study. SETTING University hospital research unit. PARTICIPANTS Fifteen healthy volunteers aged 22 to 32 years. INTERVENTIONS Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts. ...
متن کاملNew strategies to improve the intranasal absorption of insulin.
Recently, intranasal delivery of insulin as an alternative route of parenteral administration has been widely studied because it bears close resemblance to the 'pulsatile' pattern of endogenous insulin secretion during meal time. However, insulin is not well absorbed through nasal mucosa because of its large molecular size, hydrophilicity and low permeability through the membrane. This review d...
متن کاملA physiologically based pharmacokinetic model of organophosphate dermal absorption.
The rate and extent of dermal absorption are important in the analysis of risk from dermal exposure to toxic chemicals and for the development of topically applied drugs, barriers, insect repellents, and cosmetics. In vitro flow-through cells offer a convenient method for the study of dermal absorption that is relevant to the initial processes of dermal absorption. This study describes a physio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Hospital Pharmacy
سال: 2013
ISSN: 2047-9956,2047-9964
DOI: 10.1136/ejhpharm-2013-000276.356